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CCF642

CAT: 0804-HY-100430-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100430-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity[1].
CAS Number
346640-08-2
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; PDI
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CCF642.html
Purity
98.0
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C1N(C2=CC=C(OC)C=C2)C(S/C1=C/C3=CC=C([N+]([O-])=O)S3)=S
Molecular Formula
C15H10N2O4S3
Molecular Weight
378.45
Precautions
H302
References & Citations
[1]Vatolin S et al. Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma. Cancer Res. 2016 Jun 1;76 (11) :3340-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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