Sphingosine 1 Phosphate 4 Receptor (CT) (EDG6)

• Background:

  EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs.

• Synonyms:

  Blocking peptide for use in Western blotting with Anti-EDG6 (S1P4) (CT) (Cat. No. X1182P)

• Species Reactivity:

  Human

• Conjugation:

  Unconjugated

• Type:

  Blocking Peptide

• Applications:

  Functional Inhibition

• Field of Research:

  Signal Transduction

• Assay Principle:

  For use with EDG6 (S1P4) (CT) polyclonal antibody (Cat. No. X1182P).

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided in solution at 1 mg/mL in phosphate buffered saline.

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis:

  WB