L17E

• Description:

  L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1) . L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles[1][2][3][4][5][6].

• UNSPSC:

  12352209

• Target:

  Potassium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/l17e.html

• Purity:

  99.66

• Solubility:

  H2O : ≥ 100 mg/mL

• Smiles:

  CC(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H]([C@H](CC)C)N)=O)=O)CC(C)C)=O)[C@@H](C)O)=O)C)=O)CC(C)C)=O)CCCCN)=O)CC3=CC=CC=C3)=O)CC(C)C)=O)=O)CCCCN)=O)CC4=CN=CN4)=O)C)=O)C)=O)CCCCN)=O)CC5=CN=CN5)=O)CCC(O)=O)=O)C)=O)CCCCN)=O)CCC(N)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CO)=O)CCCCN)=O)C(N)=O)C

• Molecular Formula:

  C134H220N38O31

• Molecular Weight:

  2859.42

• References & Citations:

  [1]Dogan Can Kirman, et al. Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis. Cell Death Dis. 2022 Feb 23;13 (2) :172.|[2]Nomura Y, et al. Improved cytosolic delivery of macromolecules through dimerization of attenuated lytic peptides. Bioorg Med Chem Lett. 2020 Sep 1;30 (17) :127362.|[3]Akishiba M, et al. Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide. Nat Chem. 2017 Aug;9 (8) :751-761.|[4]Du W, et al. Biodegradable silica nanocapsules enable efficient nuclear-targeted delivery of native proteins for cancer therapy. Biomaterials. 2023 Mar;294:122000. |[5]Kuriyama M, et al. KCNN4 as a genomic determinant of cytosolic delivery by the attenuated cationic lytic peptide L17E. Mol Ther. 2025 Feb 5;33 (2) :595-614.|[6]He, Jinjun, et al. Coating tetrahedral DNA framework with endosomolytic peptides for improved stability and cytosolic delivery. Advanced Sensor and Energy Materials 3.2 (2024) : 100098.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  Phase 2

• CAS Number:

  [1898254-09-5]