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L17E

CAT: 0804-HY-P4121-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P4121-01Size:5 mg
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Description
L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1) . L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles[1][2][3][4][5][6].
CAS Number
[1898254-09-5]
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l17e.html
Purity
99.66
Solubility
H2O : ≥ 100 mg/mL
Smiles
CC(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H]([C@H](CC)C)N)=O)=O)CC(C)C)=O)[C@@H](C)O)=O)C)=O)CC(C)C)=O)CCCCN)=O)CC3=CC=CC=C3)=O)CC(C)C)=O)=O)CCCCN)=O)CC4=CN=CN4)=O)C)=O)C)=O)CCCCN)=O)CC5=CN=CN5)=O)CCC(O)=O)=O)C)=O)CCCCN)=O)CCC(N)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CO)=O)CCCCN)=O)C(N)=O)C
Molecular Formula
C134H220N38O31
Molecular Weight
2859.42
References & Citations
[1]Dogan Can Kirman, et al. Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis. Cell Death Dis. 2022 Feb 23;13 (2) :172.|[2]Nomura Y, et al. Improved cytosolic delivery of macromolecules through dimerization of attenuated lytic peptides. Bioorg Med Chem Lett. 2020 Sep 1;30 (17) :127362.|[3]Akishiba M, et al. Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide. Nat Chem. 2017 Aug;9 (8) :751-761.|[4]Du W, et al. Biodegradable silica nanocapsules enable efficient nuclear-targeted delivery of native proteins for cancer therapy. Biomaterials. 2023 Mar;294:122000. |[5]Kuriyama M, et al. KCNN4 as a genomic determinant of cytosolic delivery by the attenuated cationic lytic peptide L17E. Mol Ther. 2025 Feb 5;33 (2) :595-614.|[6]He, Jinjun, et al. Coating tetrahedral DNA framework with endosomolytic peptides for improved stability and cytosolic delivery. Advanced Sensor and Energy Materials 3.2 (2024) : 100098.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 2

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