L17E

CAT: 931-T81966-01Size: 5 mgDry Ice: NoHazardous: No
5 mgSelected
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2305578-13-4
Bioactivity
L17E, a cationic amphiphilic peptide with endosomolytic properties, selectively disrupts the membranes of late endosomes (LEs) in an acidic environment and prevents TS5-p45-induced apoptosis in a dose-dependent manner. This peptide is internalized by cells and directed to LEs, where it compromises LE integrity and facilitates the release of their contents into the cytosol. L17E serves as a tool for probing the endosomal protein trafficking pathway [1].
Smiles
C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCCCN)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCCN)=O)C)=O)CCC(O)=O)=O)=O)CCCCN)=O)C)=O)C)=O)=O)CCCCN)=O)=O)CC(C)C)=O)=O)CCCCN)=O)CC(C)C)=O)C)=O)[C@@H](C)O)=O)CC(C)C)=O)NC([C@H]([C@H](CC)C)N)=O)C=4C=5C(NC4)=CC=CC5
Molecular Formula
C134H219N37O32
Molecular Weight
2860.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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