M-31850

• Description :

  M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor with IC50s of 6.0 μM and 3.1 μM for human HexA and human HexB, respectively. M-31850 also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Glycosidase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/m-31850.html

• Purity :

  99.79

• Solubility :

  DMSO : 5 mg/mL (ultrasonic; adjust pH to 6 with HCl)

• Smiles :

  O=C(C1=CC=CC2=C1C3=CC=C2)N(CCNCCN4C(C5=CC=CC6=C5C(C4=O)=CC=C6)=O)C3=O

• Molecular Formula :

  C28H21N3O4

• Molecular Weight :

  463.48

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Michael B Tropak, et al. High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol. 2007 Feb;14 (2) :153-64.|[2]Qi Chen, et al. Exploring unsymmetrical dyads as efficient inhibitors against the insect β-N-acetyl-D-hexosaminidase OfHex2. Biochimie. 2014 Feb;97:152-62.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [281224-40-6]