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M-31850

CAT: 0804-HY-104050-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-104050-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor with IC50s of 6.0 μM and 3.1 μM for human HexA and human HexB, respectively. M-31850 also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM[1][2].
CAS Number
281224-40-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/m-31850.html
Purity
99.79
Solubility
DMSO : 5 mg/mL (ultrasonic; adjust pH to 6 with HCl)
Smiles
O=C(C1=CC=CC2=C1C3=CC=C2)N(CCNCCN4C(C5=CC=CC6=C5C(C4=O)=CC=C6)=O)C3=O
Molecular Formula
C28H21N3O4
Molecular Weight
463.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Michael B Tropak, et al. High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol. 2007 Feb;14 (2) :153-64.|[2]Qi Chen, et al. Exploring unsymmetrical dyads as efficient inhibitors against the insect β-N-acetyl-D-hexosaminidase OfHex2. Biochimie. 2014 Feb;97:152-62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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