JANEX-1

CAT: 0804-HY-15508-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-15508-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

JANEX-1 (WHI-P131) is a potent and specific JAK3 inhibitor (estimated Ki=2.3 μM) . JANEX-1 (WHI-P131) shows potent JAK3-inhibitory activity (IC50 of 78 μM), does not inhibit JAK1 and JAK2.

CAS Number

202475-60-3

Product Name Alternative

WHI-P131; Jak3 inhibitor I

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/JANEX-1.html

Concentration

10mM

Purity

99.63

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1

Molecular Formula

C16H15N3O3

Molecular Weight

297.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5 (6) :1569-82.|[2]Oh YB, et al. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med. 2013 May 17;45:e23|[3]Uckun FM, et al. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4- (4'hydroxyphenyl) -amino-6,7- dimethoxyquinazoline. Clin Cancer Res. 1999 Oct;5 (10) :2954-62.|[4]Xia F, et al. IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma. Autophagy. 2018;14 (3) :450-464.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK3

Related Products

Catalog	Name
HY-N6838-01	1,1,1,1-Kestohexaose
HY-157129	AMPK-α1β1γ1 activator 1
HY-133623	1,1,1-Tribromoacetone
HY-149536	TWIK-1/TREK-1-IN-1
HY-W160628S	1,1,1-Trimethoxypropane-d5
HY-133630-01	1-Bromo-1,1-dichloroacetone
HY-133629	1,1,1,3-Tetrachloroacetone
HY-W881439-01	1- (1,1-Dimethylethyl) tridecanedioate
HY-W032015S1	1-Bromooctane-1,1-d2
HY-112773-01	1,1′,1′′,1′′′-[1,4-Piperazinediylbis (2,1-ethanediylnitrilo) ]tetrakis[2-dodecanol]

Alternative Products

Catalog	Name
S5903-01	JANEX-1
164560	Janex 1
T202764-01	JANEX-1-M
A15134-10	JANEX-1 10mg
A15134-500	JANEX-1 500mg
A15134-100	JANEX-1 100mg
A15134-25	JANEX-1 25mg
A15134-5	JANEX-1 5mg
T88730-01	JANEX-1 hydrochloride
A15134-50	JANEX-1 50mg

JANEX-1

Related Products

Alternative Products

Popular Products