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Rasagiline (Standard)

CAT: 0804-HY-14605AR-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14605AR-01Size:5 mg
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Description
Rasagiline (Standard) is the analytical standard of Rasagiline. This product is intended for research and analytical applications. Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43?nM and 412?nM for rat brain MAO B and A activity, respectively[1]. Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
136236-51-6
Product Name Alternative
(R) -AGN1135 (Standard) ; TVP1012 (Standard)
UNSPSC
12352005
Target
Monoamine Oxidase; Reference Standards
Type
Reference Standards
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rasagiline-standard.html
Smiles
C#CCN[C@H]1C2=CC=CC=C2CC1
Molecular Formula
C12H13N
Molecular Weight
171.24
References & Citations
[1]M B Youdim, et al. Rasagiline [N-propargyl-1R (+) -aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol. 2001 Jan;132 (2) :500-6.|[2]Shawna Tazik, et al. Comparative neuroprotective effects of Rasagiline and aminoindan with selegiline on dexamethasone-induced brain cell apoptosis. Neurotox Res. 2009 Apr;15 (3) :284-90.|[3]Nadia Stefanova, et al. Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Exp Neurol. 2008 Apr;210 (2) :421-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Rasagiline

Rasagiline is an indane that consists of 1-aminoindane bearing an N-propargyl substituent. A selective, irreversible monoamine oxidase-B inhibitor. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and a neuroprotective agent. It is a secondary amine, a member of indanes and a terminal acetylenic compound.

CAS Number136236-51-6
PubChem CID3052776
IUPAC Name(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
Molecular FormulaC12H13N
Molecular Weight171.24
XLogP1.8
Topological Polar Surface Area12
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Heavy Atom Count13
Formal Charge0
Complexity212
SMILES
C#CCN[C@@H]1CCC2=CC=CC=C12
InChI
InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1
InChIKey
RUOKEQAAGRXIBM-GFCCVEGCSA-N
Chemical Structure
2D Structure
2D structure of Rasagiline
CAS: 136236-51-6
CID: 3052776
Formula: C12H13N
MW: 171.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight171.24
XLogP31.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass171.104799419
Monoisotopic Mass171.104799419
Topological Polar Surface Area12 Ų
Heavy Atom Count13
Formal Charge0
Complexity212
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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