Rasagiline

CAT: 0804-HY-14605A-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-14605A-01Size:50 mg

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Description

Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively[1]. Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

CAS Number

136236-51-6

Product Name Alternative

(R) -AGN1135; TVP1012

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rasagiline.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 5.88 mg/mL

Smiles

C#CCN[C@H]1C2=CC=CC=C2CC1

Molecular Formula

C12H13N

Molecular Weight

171.24

Precautions

H302, H315, H319, H335

References & Citations

[1]M B Youdim, et al. Rasagiline [N-propargyl-1R (+) -aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol. 2001 Jan;132 (2) :500-6.|[2]Shawna Tazik, et al. Comparative neuroprotective effects of Rasagiline and aminoindan with selegiline on dexamethasone-induced brain cell apoptosis. Neurotox Res. 2009 Apr;15 (3) :284-90.|[3]Nadia Stefanova, et al. Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Exp Neurol. 2008 Apr;210 (2) :421-7.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

MAO-A; MAO-B

Citation 01

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Rasagiline

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