SR 57227A

• Description:

  SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H315, H319, H335

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/sr-57227a.html

• Purity:

  99.76

• Solubility:

  DMSO : 8.33 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

• Smiles:

  ClC1=NC(N2CCC(N)CC2)=CC=C1.[H]Cl

• Molecular Formula:

  C10H15Cl2N3

• Molecular Weight:

  248.15

• Precautions:

  H301, H315, H319, H335

• References & Citations:

  [1]Poncelet M, et al, Le Fur G. Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J Neural Transm Gen Sect. 1995;102 (2) :83‐90.|[2]Bachy A, et al. SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur J Pharmacol. 1993;237 (2-3) :299‐309.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [77145-61-0]