TAPI-0

CAT: 0804-HY-118694-03Size: 10 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-118694-03Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing[1][2].

CAS Number

163958-73-4

UNSPSC

12352209

Hazard Statement

H301

Target

Bacterial; MMP; TNF Receptor

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/tapi-0.html

Purity

98.98

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

ONC(C[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC1=CC2=C(C=C1)C=CC=C2)=O)CC(C)C)=O

Molecular Formula

C24H32N4O5

Molecular Weight

456.53

Precautions

H301

References & Citations

[1]Amit Balakrishnan, et al. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J Biol Chem. 2006 Jun 16;281 (24) :16691-9.|[2]Shiori Haga, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85 (3) :551-5.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Tapi-0

CAS Number	163958-73-4
PubChem CID	9955704
IUPAC Name	(2R)-N-[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
Molecular Formula	C24H32N4O5
Molecular Weight	456.5
XLogP	1.9
Topological Polar Surface Area	151
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	11
Heavy Atom Count	33
Formal Charge	0
Complexity	698

SMILES

C[C@@H](C(=O)N)NC(=O)[C@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CC(C)C)CC(=O)NO

InChI

InChI=1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19+,20-/m0/s1

InChIKey

CRCPLBFLOSEABN-BEVDRBHNSA-N

Chemical Structure

2D Structure

CAS: 163958-73-4

CID: 9955704

Formula: C24H32N4O5

MW: 456.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	456.5
XLogP3	1.9
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	11
Exact Mass	456.23727013
Monoisotopic Mass	456.23727013
Topological Polar Surface Area	151 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	698
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-16657-01	TAPI-1
HY-100211-01	TAPI-2
HY-100211A	(R) -TAPI-2
HY-100211R	TAPI-2 (Standard)
HY-16657A-01	(S, S) -TAPI-1
HY-143695-01	16:0 TAP
HY-113123-01	LysoPC (14:0/0:0)
HY-177978	LysoPE (P-16:0/0:0)
HY-113123S1-01	LysoPC (14:0/0:0) -d7
HY-W110794-01	Crystal violet, IND (0.0-2.0)

Alternative Products

Catalog	Name
BA1309-5	TAPI-0
M30787	TAPI 0
A13724-50	TAPI-0 50mg
A13724-5	TAPI-0 5mg
A13724-1	TAPI-0 1mg
A13724-100	TAPI-0 100mg
A13724-25	TAPI-0 25mg
A13724-2	TAPI-0 2mg
5523/1	TAPI 0 1 mg
MBS406190-01	TAPI-2

TAPI-0

Chemical Information

Related Products

Alternative Products

Popular Products