Recombinant Mouse IL-17 RA/IL-17 R Protein(Fc Tag)
CAT:
763-PDMM100153-02
Size:
20 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Mouse IL-17 RA/IL-17 R Protein(Fc Tag)
- Background: Interleukin-17 receptor (IL-17R) , also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217) , is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors , this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections , selective against Candida. It is characterized by persistent and/or recurrent infections of the skin , nails , and mucous membranes caused by organisms of the genus Candida , mainly Candida albicans.
- Abbreviation: IL-17 RA/IL-17 R
- Synonyms: Il17r, Il17ra, IL-7R, IL-17R, CDw217, IL-7R&, alpha, AW538159, Cdw217, VDw217
- CAS Number: 9000-83-3
- UniProt: Q60943
- Accession Number: Q60943
- Host: Mammalian
- Origin Species: Mouse
- Tag: C-Fc
- Sequence: Ser32-Trp322
- Purity: > 90% as determined by reducing SDS-PAGE.
- Bioactivity: Not validated for activity
- Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
- Molecular Weight: 80 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.