Recombinant Mouse Interleukin-17/IL-17 Protein

• Background:

  IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO) . High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

• Abbreviation:

  Interleukin-17; IL-17

• Synonyms:

  IL-17CTLA; Cytotoxic T-lymphocyte-associated antigen; IL-17Acytotoxic T-lymphocyte-associated protein; CTLA8cytotoxic T-lymphocyte-associated serine esterase; CTLA 8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Ctla9; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; Interleukin-17A; IL-17; CTLA-8; Il17a; Cytotoxic T-lymphocyte-associated antigen 8; Ctla8; Il17; CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8

• UniProt:

  Q62386

• Accession Number:

  Q62386

• Expression System:

  E.coli

• Tag:

  C-His

• Sequence:

  Thr 22-Ala158

• Applications:

  Cell culture

• Endotoxin:

  < 0.1 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 98 % as determined by reducing SDS-PAGE.

• Bioactivity:

  50 1 x 106 IU/mg.6

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  15.9 kDa

• Observed Molecular Weight:

  17 kDa

• Species:

  Mouse