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Risedronic acid-d4

CAT: 0804-HY-B0148SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0148SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC50 of 20.3 μM)[2][3][4].
CAS Number
1035438-80-2
Product Name Alternative
Risedronate-d4
UNSPSC
12352005
Target
Apoptosis; Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Others
Field of Research
Cancer; Infection; Metabolic Disease
Solubility
10 mM in DMSO
Smiles
C(CC=1C(=C(C(=NC1[2H])[2H])[2H])[2H])(P(=O)(O)O)(P(=O)(O)O)O
Molecular Formula
C7H7D4NO7P2
Molecular Weight
287.14
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Fujita H, et al. Effect of risedronate on osteoblast differentiation, expression of receptor activator of NF-κB ligand and apoptosis in mesenchymal stem cells. Basic Clin Pharmacol Toxicol. 2011 Aug;109 (2) :78-84. |[3]Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55 (5) :2026-31.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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