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Hydrochlorothiazide

CAT: 0804-HY-B0252-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0252-01Size:500 mg
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Description
Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].
CAS Number
58-93-5
Product Name Alternative
HCTZ
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel; TGF-beta/Smad
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Hydrochlorothiazide.html
Purity
99.46
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=C(Cl)C=C(C2=C1)NCNS2(=O)=O)(N)=O
Molecular Formula
C7H8ClN3O4S2
Molecular Weight
297.75
Precautions
H302, H315, H319, H335
References & Citations
[1]Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8 (6) : p. 793-802.|[2]Magdy M Abdelquader, et al. Inhibition of Co-Crystallization of Olmesartan Medoxomil and Hydrochlorothiazide for Enhanced Dissolution Rate in Their Fixed Dose Combination. AAPS PharmSciTech. 2018 Dec 17;20 (1) :3.|[3]Jinghong Luo, et al. Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. Cardiovasc Ther. 2017 Apr;35 (2) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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