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ML404

CAT: 0804-HY-114898Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114898Size:1 Each
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Description
ML404 (Compound 38) is an inhibitor of the mitochondrial permeability transition pore (mtPTP), which can suppress mitochondrial swelling (EC50=4.9 nM) and only disrupts mitochondrial coupling (an adverse effect) at concentrations > 100 μM. ML404 can be utilized in research related to multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), muscular dystrophies (MD), myocardial infarction, and stroke[1].
CAS Number
1826026-00-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ml404.html
Smiles
O=C(NC1=CC(Cl)=CC=C1C)C2=NOC(C3=CC=CC(O)=C3)=C2
Molecular Formula
C17H13ClN2O3
Molecular Weight
328.75
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Sileikyte J, et al. Small molecules targeting the mitochondrial permeability transition[J]. Probe Reports from the NIH Molecular Libraries Program [Internet], 2015.|[2]Roy S, et al. Discovery, synthesis, and optimization of diarylisoxazole‐3‐carboxamides as potent inhibitors of the mitochondrial permeability transition pore[J]. ChemMedChem, 2015, 10 (10) : 1655-1671.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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