TRPC6-PAM-C20
CAT:
804-HY-136190-01
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TRPC6-PAM-C20
- CAS Number: 667427-75-0
- UNSPSC Description: TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals[1].
- Target Antigen: TRP Channel
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/trpc6-pam-c20.html
- Smiles: O=C1C(C2=NC(C)(C)CC3=C2C=C(OC)C(OC)=C3)=CC4=CC=CC=C4O1
- Molecular Weight: 363.41
- References & Citations: [1]S Häfner, et al. Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium. 2019 Mar;78:26-34.
- Shipping Conditions: Room Temperature