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E6130

CAT: 0804-HY-107456-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107456-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E6130 is an orally active and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease.
CAS Number
1427058-33-0
UNSPSC
12352005
Target
CX3CR1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/E6130.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : ≥ 250 mg/mL
Smiles
C[C@@H](C1)[C@@](C(NC2CCN(CC3=CCCCC3)CC2)=O)(CC(O)=O)CN1CC4=C(C(F)(F)F)C=CC=C4Cl
Molecular Formula
C28H37ClF3N3O3
Molecular Weight
556.06
References & Citations
[1]Wakita H, et al. E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1+ Leukocyte Trafficking in Mice with Colitis. Mol Pharmacol. 2017 Nov;92 (5) :502-509.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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