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Propargyl-PEG3-acid

CAT: 0804-HY-126975-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126975-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA and Propargyl-PEG3-acid[1]. Propargyl-PEG3-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
1347760-82-0
UNSPSC
12352203
Hazard Statement
H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/propargyl-peg3-acid.html
Purity
99.14
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCOCCOCCOCC#C
Molecular Formula
C10H16O5
Molecular Weight
216.23
Precautions
H315, H319, H335
References & Citations
[1]Farzam A, et al. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biol. 2020 Jan;28:101377.|[2]Albone, Earl F, et al. ERIBULIN-BASED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE. Patent. 20170252458.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers

Chemical Information

Propargyl-PEG3-Carboxylic Acid
CAS Number1347760-82-0
PubChem CID60146217
IUPAC Name3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoic acid
Molecular FormulaC10H16O5
Molecular Weight216.23
XLogP-0.6
Topological Polar Surface Area65
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Heavy Atom Count15
Formal Charge0
Complexity205
SMILES
C#CCOCCOCCOCCC(=O)O
InChI
InChI=1S/C10H16O5/c1-2-4-13-6-8-15-9-7-14-5-3-10(11)12/h1H,3-9H2,(H,11,12)
InChIKey
CJNSWLAJTZVSRB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Propargyl-PEG3-Carboxylic Acid
CAS: 1347760-82-0
CID: 60146217
Formula: C10H16O5
MW: 216.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight216.23
XLogP3-0.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass216.09977361
Monoisotopic Mass216.09977361
Topological Polar Surface Area65 Ų
Heavy Atom Count15
Formal Charge0
Complexity205
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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