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Bis-propargyl-PEG3

CAT: 0804-HY-133192-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133192-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity[1] [2]. Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
126422-58-0
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/bis-propargyl-peg3.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C#CCOCCOCCOCCOCC#C
Molecular Formula
C12H18O4
Molecular Weight
226.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.|[2]Rice DR, et al. Antiplasmodial activity of targeted zinc (II) -dipicolylamine complexes. Bioorg Med Chem. 2017 May 15;25 (10) :2754-2760.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

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