Bis-propargyl-PEG3

• Description:

  Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity[1] [2]. Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/bis-propargyl-peg3.html

• Purity:

  98.88

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C#CCOCCOCCOCCOCC#C

• Molecular Formula:

  C12H18O4

• Molecular Weight:

  226.27

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.|[2]Rice DR, et al. Antiplasmodial activity of targeted zinc (II) -dipicolylamine complexes. Bioorg Med Chem. 2017 May 15;25 (10) :2754-2760.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PEG Linkers

• CAS Number:

  [126422-58-0]