Doxepin-d3 (hydrochloride)

Doxepin-d3 (hydrochloride)

• CAS Number: 347840-07-7
• UNSPSC Description: Doxepin-d3 (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].
• Target Antigen: Cytochrome P450; Histamine Receptor
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Purity: 98.68
• Solubility: 10 mM in DMSO
• Smiles: [2H]C(N(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C\13)([2H])[2H].[H]Cl
• Molecular Weight: 318.86
• References & Citations: [1]Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62(6): p. 453-63.|[2]Gillman PK1. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151(6):737-48.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported