Doxepin

• Description:

  Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis, chronic urticarial, can improve cognitive processes, protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress[1][2][3].

• UNSPSC:

  12352005

• Target:

  Akt; mTOR; PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/doxepin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C/13

• Molecular Formula:

  C19H21NO

• Molecular Weight:

  279.38

• References & Citations:

  [1]AnnemiekVermeeren, et al. Effects of the use of hypnotics on cognition. Progress in brain research vol. 190 (2011) : 89-103.|[2]G Hajak, et al. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. The Journal of clinical psychiatry vol. 62,6 (2001) : 453-63.|[3]Mahsa Gharzi, et al. Effects of different doses of doxepin on passive avoidance learning in rats. Advanced biomedical research vol. 2 66. 30 Jul. 2013. |[4]Jimei Bu, et al. Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats. Iran J Basic Med Sci. 2017 Sep;20 (9) :1044-1049.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  J Appl Toxicol. 2023 Oct;43 (10) :1421-1435.|Nat Commun. 2022 Nov 10;13 (1) :6796.|Antiviral Res. 2025 Dec:244:106307.|Cell Commun Signal. 2023 May 25;21 (1) :123.|Pharm Res. 2025 Aug;42 (8) :1315-1329.|Virus Res. 2022 Aug:317:198816.

• CAS Number:

  [1668-19-5]