Doxepin

CAT: 0804-HY-B0725ASize: 1 EachDry Ice: NoHazardous: No

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Description

Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis, chronic urticarial, can improve cognitive processes, protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress[1][2][3].

CAS Number

1668-19-5

UNSPSC

12352005

Target

Akt; mTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/doxepin.html

Solubility

10 mM in DMSO

Smiles

CN(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C/13

Molecular Formula

C19H21NO

Molecular Weight

279.38

References & Citations

[1]AnnemiekVermeeren, et al. Effects of the use of hypnotics on cognition. Progress in brain research vol. 190 (2011) : 89-103.|[2]G Hajak, et al. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. The Journal of clinical psychiatry vol. 62,6 (2001) : 453-63.|[3]Mahsa Gharzi, et al. Effects of different doses of doxepin on passive avoidance learning in rats. Advanced biomedical research vol. 2 66. 30 Jul. 2013. |[4]Jimei Bu, et al. Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats. Iran J Basic Med Sci. 2017 Sep;20 (9) :1044-1049.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

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Doxepin

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