5β-Dihydrocortisol

• Description:

  5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].

• UNSPSC:

  12352211

• Hazard Statement:

  H360, H373

• Target:

  Apoptosis; Drug Metabolite

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/5β-dihydrocortisol.html

• Purity:

  99.70

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  C[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CC[C@@](C3)([H])[C@@]4(CCC3=O)C)([H])[C@]4([H])[C@@H](O)C1

• Molecular Formula:

  C21H32O5

• Molecular Weight:

  364.48

• Precautions:

  H360, H373

• References & Citations:

  [1]Marver D, et, al. Dihydrocortisol: a potential mineralocorticoid. J Steroid Biochem. 1978 Jan;9 (1) :1-7.|[2]Kallubai M, et, al. Spectroscopic evaluation of synthesized 5β-dihydrocortisol and 5β-dihydrocortisol acetate binding mechanism with human serum albumin and their role in anticancer activity. J Biomol Struct Dyn. 2019 Feb;37 (3) :623-640.|[3]Southren AL, et, al. 5 beta-Dihydrocortisol: possible mediator of the ocular hypertension in glaucoma. Invest Ophthalmol Vis Sci. 1985 Mar;26 (3) :393-5.|[4]Appanna N, et, al. Differential activity and expression of human 5β-reductase (AKR1D1) splice variants. J Mol Endocrinol. 2021 Mar;66 (3) :181-194.|[5]Weinstein BI, et, al. Potentiation of glucocorticoid activity by 5 beta-dihydrocortisol: its role in glaucoma. Science. 1983 Oct 14;222 (4620) :172-3.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [1482-50-4]