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6,7-Dimethylisatin

CAT: 0804-HY-W029600-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W029600-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6,7-Dimethylisatin (compound 1l), an Isatin analogue, is a potent MAO inhibitor with IC50s of 20.3 μM and 6.74 μM for MAO-A and MAO-B, respectively. 6,7-Dimethylisatin has the potential for depression, Alzheimer's disease and Parkinson's disease research[1].
CAS Number
20205-43-0
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/6-7-dimethylisatin.html
Smiles
O=C1NC2=C(C)C(C)=CC=C2C1=O
Molecular Formula
C10H9NO2
Molecular Weight
175.18
Precautions
P264-P280-P302+P352-P362+P364
References & Citations
[1]Izak F Prinsloo, et al. The evaluation of isatin analogues as inhibitors of monoamine oxidase. Chem Biol Drug Des. 2023 Nov;102 (5) :1067-1074.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-A; MAO-B

Chemical Information

6,7-dimethyl-2,3-dihydro-1H-indole-2,3-dione
CAS Number20205-43-0
PubChem CID1810511
IUPAC Name6,7-dimethyl-1H-indole-2,3-dione
Molecular FormulaC10H9NO2
Molecular Weight175.18
XLogP1.4
Topological Polar Surface Area46.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Heavy Atom Count13
Formal Charge0
Complexity262
SMILES
CC1=C(C2=C(C=C1)C(=O)C(=O)N2)C
InChI
InChI=1S/C10H9NO2/c1-5-3-4-7-8(6(5)2)11-10(13)9(7)12/h3-4H,1-2H3,(H,11,12,13)
InChIKey
GVRLEGBOODEAOX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6,7-dimethyl-2,3-dihydro-1H-indole-2,3-dione
CAS: 20205-43-0
CID: 1810511
Formula: C10H9NO2
MW: 175.18
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight175.18
XLogP31.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass175.063328530
Monoisotopic Mass175.063328530
Topological Polar Surface Area46.2 Ų
Heavy Atom Count13
Formal Charge0
Complexity262
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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