Triamcinolone acetonide

Triamcinolone acetonide

• CAS Number: 76-25-5
• UNSPSC Description: Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis[1][2][3][4].
• Target Antigen: FGFR; Glucocorticoid Receptor
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Protein Tyrosine Kinase/RTK;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Endocrinology; Inflammation/Immunology; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/Triamcinolone-acetonide.html
• Purity: 99.75
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
• Smiles: OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@H](C3)O)([C@@]5(C(CC4)=CC(C=C5)=O)C)F)([H])C[C@@]1([H])OC(C)(O2)C)C)=O
• Molecular Weight: 434.50
• References & Citations: [1]http://en.wikipedia.org/wiki/Triamcinolone_acetonide|[2]Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16(13):2382-2391.|[3]Spandau U H M, et al. Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo [J]. British journal of ophthalmology, 2005, 89(6): 745-747.|[4]Euppayo T, et al. In vitro effects of triamcinolone acetonide and in combination with hyaluronan on canine normal and spontaneous osteoarthritis articular cartilage [J]. In Vitro Cellular & Developmental Biology-Animal, 2016, 52: 723-735.|[5]Siebelt M, et al. Triamcinolone acetonide activates an anti-inflammatory and folate receptor–positive macrophage that prevents osteophytosis in vivo [J]. Arthritis research & therapy, 2015, 17(1): 1-13.|[6]Jensen J M, et al. Effects of pimecrolimus compared with triamcinolone acetonide cream on skin barrier structure in atopic dermatitis: a randomized, double-blind, right–left arm trial [J]. Acta Dermato-Venereologica, 2013, 93(5): 515-519.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched