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Triamcinolone acetonide

CAT: 0804-HY-B0636-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0636-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis[1][2][3][4].
CAS Number
76-25-5
UNSPSC
12352005
Hazard Statement
H360
Target
FGFR; Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Endocrinology; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Triamcinolone-acetonide.html
Purity
99.95
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@H](C3)O)([C@@]5(C(CC4)=CC(C=C5)=O)C)F)([H])C[C@@]1([H])OC(C)(O2)C)C)=O
Molecular Formula
C24H31FO6
Molecular Weight
434.50
Precautions
H360
References & Citations
[1]http://en.wikipedia.org/wiki/Triamcinolone_acetonide|[2]Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16 (13) :2382-2391.|[3]Spandau U H M, et al. Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo [J]. British journal of ophthalmology, 2005, 89 (6) : 745-747.|[4]Euppayo T, et al. In vitro effects of triamcinolone acetonide and in combination with hyaluronan on canine normal and spontaneous osteoarthritis articular cartilage [J]. In Vitro Cellular & Developmental Biology-Animal, 2016, 52: 723-735.|[5]Siebelt M, et al. Triamcinolone acetonide activates an anti-inflammatory and folate receptor–positive macrophage that prevents osteophytosis in vivo [J]. Arthritis research & therapy, 2015, 17 (1) : 1-13.|[6]Jensen J M, et al. Effects of pimecrolimus compared with triamcinolone acetonide cream on skin barrier structure in atopic dermatitis: a randomized, double-blind, right–left arm trial [J]. Acta Dermato-Venereologica, 2013, 93 (5) : 515-519.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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