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Guangxitoxin 1E (TFA)

CAT: 0804-HY-P1427ASize: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1427ASize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Guangxitoxin 1E TFA is the TFA salt form of Guangxitoxin 1E. Guangxitoxin 1E TFA is a peptide toxin and a selective inhibitor for voltage-gated potassium channel KV2.1 and KV2.2 with IC50 of 1-3 nM. Guangxitoxin 1E TFA enhances glucose-stimulated intracellular calcium ion oscillations and increases insulin secretion in a glucose-dependent manner[1].
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/guangxitoxin-1e-tfa.html
Purity
97.44
Solubility
H2O : 100 mg/mL
Smiles
O=C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@H]3C(C)C)=O)=O)=O)=O)NC4=O)C(NCC(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CC8=CNC9=CC=CC=C89)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N%10[C@@H](CCC%10)C(N[C@@H](CCCCN)C(N[C@@H](CC(/C%11=C/C)=CNC%11=C)C(NCC(N[C@H]%12CC(C)C)=O)=O)=O)=O)=O)=O)NC3=O)C(NCC(N[C@@H](CO)C(NCC(N[C@@H](CCCCN)C(N%13[C@@H](CCC%13)C(N[C@@H](C)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CC%14=CC=CC=C%14)C(N%15[C@@H](CCC%15)C(N[C@@H](CCSC)C(N%16[C@@H](CCC%16)C(O)=O)=O)=O)=O)=O)=O)NC%12=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N.OC(C(F)(F)F)=O.[x]
Molecular Formula
C178H248N44O45S7.xC2HF3O2
Molecular Weight
3948.61 (free base)
References & Citations
[1]Herrington J, et al. Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. 2006 Apr;55 (4) :1034-42.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel

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