L-873724

CAT: 0804-HY-50887-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-50887-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

L-873724 is a potent, orally bioavailable, selective and reversible[2] non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively[1]. L-873724 also exhibits an IC50 of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption[2].

CAS Number

603139-12-4

UNSPSC

12352005

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/MK-0822.html

Purity

98.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(C2=CC=C([C@@H](C(F)(F)F)N[C@@H](CC(C)C)C(NCC#N)=O)C=C2)C=C1)(C)=O

Molecular Formula

C23H26F3N3O3S

Molecular Weight

481.53

References & Citations

[1]Li CS, et al. Identification of a potent and selective non-basic cathepsin K inhibitor. Bioorg Med Chem Lett. 2006 Apr 1;16 (7) :1985-9.|[2]Zhuo Y, et al. Inhibition of bone resorption by the cathepsin K inhibitor odanacatib is fully reversible. Bone. 2014 Oct;67:269-80.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cathepsin B; Cathepsin K

Related Products

Catalog	Name
HY-W928653	L-Seryl-L-leucyl-L-leucyl-L-lysine
HY-101552A-01	L, L-Dityrosine
HY-P4621-01	L-Alanyl-L-alanyl-L-glutamine
HY-W010789-01	L-Lysyl-L-tyrosine-α-L-lysine
HY-P4257	L-Isoleucyl-L-arginine
HY-129263-01	L-Isoleucyl-L-valine
HY-W101499-01	L-a-Aspartyl-L-leucine
HY-W101298-01	L-Leucyl-L-isoleucine
HY-W011607-01	L-Alanyl-L-tryptophan
HY-112171-01	γ-L-Glutamyl-L-alanine

Alternative Products

Catalog	Name
T16092-01	L-873724
M15251-01	L 873724
A12487-5	L-873724 5mg
A12487-1	L-873724 1mg
A12487-10	L-873724 10mg
A12487-25	L-873724 25mg
MAB8056	Human Insulin MAb (Clone 873724)
CCP1053-01	A-L-A-L
453309-01	L-Glycyl-L-lysyl-L-leucyl-L-isoleucyl-L-tyrosyl-L-seryl-L-alanyl-L-seryl-L-phenylalanyl-L-leucyl-L-tyrosyl-L-seryl-L-glycyl-L-valyl-L-prolyl-L-seryl-L-arganine
453434-01	L-Seryl-L-threonyl-L-glycyl-L-isoleucyl-L-seryl-L-valyl-L-prolyl-L-glycyl-L-prolyl-L-methionyl-L-glycyl-L-prolyl-L-seryl-L-glycyl-L-prolyl-L-Arginine

L-873724

Related Products

Alternative Products

Popular Products