PROTAC MLKL Degrader-1

PROTAC MLKL Degrader-1

• CAS Number: 3032600-90-8
• UNSPSC Description: PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL, with a Dmax ＞90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide (HY-A0003)-linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.
• Target Antigen: Mixed Lineage Kinase; PROTACs
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/protac-mlkl-degrader-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=C(NN=C1C2=CC=C(C=C2)NS(C(F)F)(=O)=O)NC3=CC=CC(OCCCCCCCC(N4CCC5(CCN(CC5)C(C6=CC=C(C(N7CCC(NC7=O)=O)=C6)OC)=O)CC4)=O)=C3)N
• Molecular Weight: 948.05
• References & Citations: [1]Rathje OH, Perryman L, Payne RJ, Hamprecht DW. PROTACs Targeting MLKL Protect Cells from Necroptosis. J Med Chem. 2023 Aug 3.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported