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7α-Hydroxy-DHEA

CAT: 0804-HY-145751-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145751-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA , catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma[1].
CAS Number
53-00-9
Product Name Alternative
7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one
UNSPSC
12352211
Target
Cytochrome P450; Mitochondrial Metabolism
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/7α-hydroxy-dhea.html
Smiles
C[C@@]12[C@]3([H])[C@]([C@@H](C=C1C[C@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C
Molecular Formula
C19H28O3
Molecular Weight
304.42
References & Citations
[1]Lardy H, et al. Ergosteroids. II: Biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids. 1998 Mar;63 (3) :158-65. |[2]OKADA M, et al. Isolation and characterization of 3 beta-hydroxy-delta 5-steroids in adrenal carcinoma. J Biol Chem. 1959 Jul;234 (7) :1688-92.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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