7α-Hydroxy-DHEA

• Description :

  7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma[1].

• CAS Number :

  [53-00-9]

• Product Name Alternative :

  7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one

• UNSPSC :

  12352211

• Target :

  Cytochrome P450; Mitochondrial Metabolism

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/7α-hydroxy-dhea.html

• Smiles :

  C[C@@]12[C@]3([H])[C@]([C@@H](C=C1C[C@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C

• Molecular Formula :

  C19H28O3

• Molecular Weight :

  304.42

• References & Citations :

  [1]Lardy H, et al. Ergosteroids. II: Biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids. 1998 Mar;63 (3) :158-65. |[2]OKADA M, et al. Isolation and characterization of 3 beta-hydroxy-delta 5-steroids in adrenal carcinoma. J Biol Chem. 1959 Jul;234 (7) :1688-92.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported