HOME3 rabbit pAb

CAT: 0855-ES15689-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES15689-01Size:50 µL

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Background

This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Description

This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1, 4, 5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009],

UniProt

Q9NSC5

Swiss Prot

Q9NSC5

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human HOME3 AA range: 243-293

Target

HOME3

Clonality

Polyclonal

Source

Rabbit

Applications

Concentration

1 mg/ml

Dilution

WB 1:500-2000

Buffer

-20°C/1 year

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Postsynaptic density of neuronal cells. .

Gene ID (Human)

9454

UniProtKB · Q9NSC5

Homer protein homolog 3

HOME3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9NSC5
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: HOMER3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Homer-3
EC number: —
Processing: —
Secondary accessions: B2RA10, E9PCW9, O14580, O95350, Q9NSB9, Q9NSC0, Q9NSC1

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Domain

Coiled coil

Cellular component

CytoplasmSynapse

PTM

Phosphoprotein

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RA32667-01	HOME3 rabbit pAb
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