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Madecassic acid

CAT: 0804-HY-N0569-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0569-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Madecassic acid is isolated from Centella asiatica (Umbelliferae) . Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells[1].
CAS Number
[18449-41-7]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
COX; Interleukin Related; NO Synthase; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/madecassic-acid.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
C[C@@]([C@]([C@H](O)C1)([H])[C@]2(C)CO)(C[C@@H](O)[C@@H]2O)[C@](CC=C3[C@]4(CC[C@@](C(O)=O)(CC[C@H]5C)[C@@]3([H])[C@H]5C)C)([H])[C@]41C
Molecular Formula
C30H48O6
Molecular Weight
504.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Won JH, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaBpathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 2010 Feb;76 (3) :251-7.|[2]Xinming Yun, et al. Madecassic acid alleviates colitis-associated colorectal cancer by blocking the recruitment of myeloid-derived suppressor cells via the inhibition of IL-17 expression in γδT17 cells. Biochem Pharmacol. 2022.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; IL-1; IL-6; iNOS; TNFRSF5/CD40

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