Madecassic acid

• Description :

  Madecassic acid is isolated from Centella asiatica (Umbelliferae) . Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells[1].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  COX; Interleukin Related; NO Synthase; TNF Receptor

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/madecassic-acid.html

• Concentration :

  10mM

• Purity :

  99.81

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  C[C@@]([C@]([C@H](O)C1)([H])[C@]2(C)CO)(C[C@@H](O)[C@@H]2O)[C@](CC=C3[C@]4(CC[C@@](C(O)=O)(CC[C@H]5C)[C@@]3([H])[C@H]5C)C)([H])[C@]41C

• Molecular Formula :

  C30H48O6

• Molecular Weight :

  504.70

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Won JH, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaBpathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 2010 Feb;76 (3) :251-7.|[2]Xinming Yun, et al. Madecassic acid alleviates colitis-associated colorectal cancer by blocking the recruitment of myeloid-derived suppressor cells via the inhibition of IL-17 expression in γδT17 cells. Biochem Pharmacol. 2022.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  COX-2; IL-1; IL-6; iNOS; TNFRSF5/CD40

• CAS Number :

  [18449-41-7]