KO-947

• Description:

  KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential utility in MAPK pathway dysregulated tumors.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ERK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/KO-947.html

• Concentration:

  10mM

• Purity:

  99.68

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles:

  O=C1NC2=CC(NN=C3C4=CC=NC=C4)=C3C=C2CN1CC5=CC=CC=C5

• Molecular Formula:

  C21H17N5O

• Molecular Weight:

  355.39

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Burrows F, et al. KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA) : AACR; Cancer Res 2017;77 (13 Suppl) :Abstract nr 5168. doi:10.1158/1538-7445.AM2017-5168.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  ERK1; ERK2

• CAS Number:

  [1695533-89-1]