Streptomycin

• UNSPSC Description:

  Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes [1][2][3].

• Target Antigen:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/streptomycin.html

• Purity:

  99.88

• Solubility:

  H2O : 125 mg/mL (ultrasonic)

• Smiles:

  N=C(N)N[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)O)NC(N)=N)O)[C@H]1O[C@H](O[C@H]([C@]2(O)C=O)C)[C@@H]2O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC

• Molecular Weight:

  581.57

• References & Citations:

  [1]J DAVIES, et al. STREPTOMYCIN, SUPPRESSION, AND THE CODE. Proc Natl Acad Sci U S A. 1964 May;51(5):883-90.|[2]Deisy M G C Rocha, et al. The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem. Genes (Basel). 2021 Dec 17;12(12):2003.|[3]Mandeep Singh, et al. Streptomycin sulphate loaded solid lipid nanoparticles show enhanced uptake in macrophage, lower MIC in Mycobacterium and improved oral bioavailability. Eur J Pharm Biopharm. 2021 Mar;160:100-124.ACS Appl Mater Interfaces. 2024 Aug 24.|Adv Sci (Weinh). 2024 Oct 7:e2401931.|APL Bioeng. 2022, 6(4): 046106.|BMC Cancer. 2023 Mar 14;23(1):241.|Cancers (Basel). 2022 Sep 28;14(19):4740.|Food Chem. 2022 Sep 26;403:134399.|Free Radic Biol Med. 2023 Apr 10;S0891-5849(23)00373-8.|Genome Biol. 2023 Apr 30;24(1):98.|Gut Microbes. 2024 Jan-Dec;16(1):2390164.|In Vitro Cell Dev Biol Anim. 2024 Jul 22.|Int J Biol Sci. 2024 Sep 3;20(12):4635-4653.|J Control Release. 2024 Oct 26:S0168-3659(24)00725-9.|J Med Chem. 2024 Aug 19.|J Orthop Surg Res. 2022 Oct 28;17(1):468.|Redox Biol. 2024 Jul 23:75:103284.|Research (Wash D C). 2024 Jul 16:7:0415.|ACS Chem Biol. 2021 Dec 15.|ACS Omega. 2020 Nov 15;5(46):29935-29942.|Autophagy. 2021 Jul 20;1-19.|Cell Rep Med. 2023 Dec 19;4(12):101340.|Dis Model Mech. 2021 Oct 13;dmm.049145.|Drug Dev Res. 2021 Aug 17.|Life Sci. 2020 Nov 15;261:118473.|Mol Med Rep. 2021 Dec;24(6):832.|Mol Med Rep. 2021 Dec;24(6):843.|NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111.|PLoS One. 2020 Sep 3;15(9):e0235824.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  57-92-1