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Streptolysin O

CAT: 0804-HY-135416Size: 25 KUDry Ice: NoHazardous: No
CAT#:0804-HY-135416Size:25 KU
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state[1][2][3][4].
CAS Number
[98072-47-0]
UNSPSC
12352211
Hazard Statement
H300+H310+H330, H315, H318, H411
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/streptolysin-o.html
Solubility
H2O : 1 mg/mL (ultrasonic)
Smiles
[StreptolysinO]
Precautions
H300+H310+H330, H315, H318, H411
References & Citations
[1]Sierig G, et al. Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorlyencapsulated group a streptococci. Infect Immun. 2003 Jan;71 (1) :446-55.|[2]Van Epps DE, et al. Streptolysin O II. Relationship of Sulfyhdryl Groups to Activity. Infect Immun. 1971 May;3 (5) :648-52.|[3]Uchiyama S, et al. Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus. Front Immunol. 2015 Nov 16;6:581.|[4]Yamamoto I, et al. Mutational and comparative analysis of streptolysin O, an oxygen-labile streptococcal hemolysin. Biosci Biotechnol Biochem. 2001 Dec;65 (12) :2682-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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