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Taspine

CAT: 0804-HY-131502-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131502-01Size:1 mg
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Description
Taspine is a natural product with anti-inflammatory activity. Taspine suppresses P2X4 receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage[1].
CAS Number
602-07-3
UNSPSC
12352005
Target
P2X Receptor
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/taspine.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC=C(OC)C(O3)=C2C4=C(C3=O)C(CCN(C)C)=CC(OC)=C4O1
Molecular Formula
C20H19NO6
Molecular Weight
369.37
References & Citations
[1]Izzuddin Bin Nadzirin, et al. Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3-kinase inhibition. Br J Pharmacol. 2021 Dec;178 (24) :4859-4872.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
P2X4 Receptor

Chemical Information

Taspine

taspine has been reported in Caulophyllum thalictroides, Gymnospermium darwasicum, and other organisms with data available.

CAS Number602-07-3
PubChem CID215159
IUPAC Name5-[2-(dimethylamino)ethyl]-7,14-dimethoxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione
Molecular FormulaC20H19NO6
Molecular Weight369.4
XLogP2.8
Topological Polar Surface Area74.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity595
SMILES
CN(C)CCC1=CC(=C2C3=C1C(=O)OC4=C(C=CC(=C34)C(=O)O2)OC)OC
InChI
InChI=1S/C20H19NO6/c1-21(2)8-7-10-9-13(25-4)18-16-14(10)20(23)27-17-12(24-3)6-5-11(15(16)17)19(22)26-18/h5-6,9H,7-8H2,1-4H3
InChIKey
MTAWKURMWOXCEO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Taspine
CAS: 602-07-3
CID: 215159
Formula: C20H19NO6
MW: 369.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight369.4
XLogP32.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass369.12123733
Monoisotopic Mass369.12123733
Topological Polar Surface Area74.3 Ų
Heavy Atom Count27
Formal Charge0
Complexity595
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
HY-116572A-01TASIN-1
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Alternative Products

CatalogName
TRC-T007800-50MGTaspine

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