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Idebenone (Standard)

CAT: 0804-HY-N0303R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0303R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Idebenone (Standard) is the analytical standard of Idebenone. This product is intended for research and analytical applications. Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC50=16.65 μM) [1]. Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells[2]. Idebenone quickly crosses the blood-brain barrier.
CAS Number
58186-27-9
UNSPSC
12352005
Target
Apoptosis; Mitochondrial Metabolism; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/idebenone-standard.html
Purity
96.98
Smiles
O=C1C(CCCCCCCCCCO)=C(C)C(C(OC)=C1OC)=O
Molecular Formula
C19H30O5
Molecular Weight
338.44
References & Citations
[1]G Civenni, et al. Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes.Eur J Pharmacol. 1999 Apr 9;370 (2) :161-7.|[2]Kwok-Keung Tai, et al. Idebenone induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells. Neurotox Res. 2011 Nov;20 (4) :321-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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