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(R) -Levrazoxane

CAT: 0804-HY-124178-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124178-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Levrazoxane ((R) -ICRF 186) is enzymatically hydrolysed to one-ring open intermediates by dihydropyrimidine amidohydrolase (DPHase), which is present in the liver and kidney. The radiosensitizing efficiency of (R) -Levrazoxane towards EMT6 mouse mammary tumour cells is greater than that of Dexrazoxane. (R) -Levrazoxane is promising for research of liver and kidney related diseases[1].
CAS Number
24613-06-7
Product Name Alternative
(R) -ICRF 186
UNSPSC
12352005
Hazard Statement
H302+H312+H332-H315-H319
Target
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/r-levrazoxane.html
Smiles
C[C@H](CN(CC(N1)=O)CC1=O)N(CC(N2)=O)CC2=O
Molecular Formula
C11H16N4O4
Molecular Weight
268.27
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Hasinoff BB, et al. Metabolism of the cardioprotective agents dexrazoxane (ICRF-187) and levrazoxane (ICRF-186) by the isolated hepatocyte. Xenobiotica. 1994 Oct;24 (10) :977-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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