Adenosine 5′-diphosphoribose (sodium)

Adenosine 5′-diphosphoribose (sodium)

• CAS Number: 68414-18-6
• UNSPSC Description: Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy[1][2].
• Target Antigen: Autophagy; TRP Channel
• Type: Reference compound
• Related Pathways: Autophagy;Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Cancer-programmed cell death
• Field of Research: Endocrinology; Metabolic Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/adenosine-5-diphosphoribose-sodium.html
• Purity: 99.03
• Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : 125 mg/mL (ultrasonic)
• Smiles: O[C@H]([C@@H]1O)[C@@H](O[C@@H]1COP(OP(OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)([O-])=O)(O)=O)N2C(N=CN=C3N)=C3N=C2.[Na+]
• Molecular Weight: 581.30
• References & Citations: [1]Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454-62.|[2] Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13440-5.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: Phase 1