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HCH6-1

CAT: 0804-HY-101283-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101283-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1) . HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist) . HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases[1].
CAS Number
1435265-06-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Formyl Peptide Receptor (FPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hch6-1.html
Purity
99.16
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(N[C@@H](C(OC)=O)CC1=CC=CC=C1)=O)CC2=CNC3=C2C=CC=C3)C4=CC=CC=C4
Molecular Formula
C28H27N3O4
Molecular Weight
469.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang SC, et al. Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1. Free Radic Biol Med. 2017 May;106:254-269
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

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BA5319-5.1HCH6-1
A20395-100HCH6-1 100mg
A20395-50HCH6-1 50mg
A20395-10HCH6-1 10mg
A20395-5HCH6-1 5mg
A20395-2HCH6-1 2mg
A20395-1HCH6-1 1mg
A20395-25HCH6-1 25mg
A20395-10mM-DHCH6-1 10mM * 1mL in DMSO
OF59775-011,1,1,1,1-Kestoheptaose

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