LETC

CAT: 0804-HY-163739-03Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-163739-03Size:25 mg

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Description

LETC is an orally active α-synuclein (α-Syn) aggregation inhibitor with an EC50 of 66 nM in transfected DH60.21 neuroblastoma cells. LETC can cross the blood-brain barrier. LETC can be used for the study of synucleinopathies[1].

CAS Number

951131-13-8

UNSPSC

12352005

Target

α-synuclein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/letc.html

Purity

98.30

Smiles

CCN(CC)C1=CC=C2C(SC3=C(N2)C=CC(N(CC)CC)=C3)=C1.Cl.Cl

Molecular Formula

C20H29Cl2N3S

Molecular Weight

414.44

References & Citations

[1]Karima Schwab, et al. LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy. Eur J Pharmacol. 2024 May 5:970:176505.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

α-synuclein Aggregation

Chemical Information

Letc

CAS Number	951131-13-8
PubChem CID	142784373
IUPAC Name	3-N,3-N,7-N,7-N-tetraethyl-10H-phenothiazine-3,7-diamine;dihydrochloride
Molecular Formula	C20H29Cl2N3S
Molecular Weight	414.4
Topological Polar Surface Area	43.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Heavy Atom Count	26
Formal Charge	0
Complexity	349

SMILES

CCN(CC)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(CC)CC.Cl.Cl

InChI

InChI=1S/C20H27N3S.2ClH/c1-5-22(6-2)15-9-11-17-19(13-15)24-20-14-16(23(7-3)8-4)10-12-18(20)21-17;;/h9-14,21H,5-8H2,1-4H3;2*1H

InChIKey

VYXKGVOTYDXAAD-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 951131-13-8

CID: 142784373

Formula: C20H29Cl2N3S

MW: 414.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	414.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	413.1459245
Monoisotopic Mass	413.1459245
Topological Polar Surface Area	43.8 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	349
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	3
Compound Is Canonicalized	Yes

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