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Tilisolol (hydrochloride)

CAT: 0804-HY-122215-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122215-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tilisolol hydrochloride (N-696) is a non-selective β-adrenergic antagonist with vasodilatory and hypotensive activities. Tilisolol hydrochloride exerts its effects in canine coronary arteries by opening ATP-sensitive K+ channels. Tilisolol hydrochloride exhibits concentration-dependent relaxation in KCl-precontracted rat thoracic aorta. Tilisolol hydrochloride reduces diastolic blood pressure in a dose-dependent manner and slightly increases heart rate in spinal cord stimulated rats[1].
CAS Number
62774-96-3
Product Name Alternative
N-696
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/tilisolol-hydrochloride.html
Smiles
O=C1C2=C(C(OCC(CNC(C)(C)C)O)=CN1C)C=CC=C2.Cl
Molecular Formula
C17H25ClN2O3
Molecular Weight
340.85
References & Citations
[1]Vasorelaxant and hypotensive effects of tilisolol hydrochloride (N-696) in isolated rat thoracic aorta and pithed rats
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Tilisolol Hydrochloride

Tilisolol hydrochloride is a member of isoquinolines.

CAS Number62774-96-3
PubChem CID5284465
IUPAC Name4-[3-(tert-butylamino)-2-hydroxypropoxy]-2-methylisoquinolin-1-one;hydrochloride
Molecular FormulaC17H25ClN2O3
Molecular Weight340.8
Topological Polar Surface Area61.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count23
Formal Charge0
Complexity428
SMILES
CC(C)(C)NCC(COC1=CN(C(=O)C2=CC=CC=C21)C)O.Cl
InChI
InChI=1S/C17H24N2O3.ClH/c1-17(2,3)18-9-12(20)11-22-15-10-19(4)16(21)14-8-6-5-7-13(14)15;/h5-8,10,12,18,20H,9,11H2,1-4H3;1H
InChIKey
SGPGESCZOCHFCL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tilisolol Hydrochloride
CAS: 62774-96-3
CID: 5284465
Formula: C17H25ClN2O3
MW: 340.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight340.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass340.1553704
Monoisotopic Mass340.1553704
Topological Polar Surface Area61.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity428
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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