O-304

• Description:

  O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  AMPK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PI3K/Akt/mTOR

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/O-304.html

• Purity:

  99.59

• Solubility:

  DMSO : 30 mg/mL (ultrasonic; warming)

• Smiles:

  O=C (NC (SN1CC2=CC=C (Cl) C=C2) =NC1=O) C3=CC=C (Cl) C=C3

• Molecular Formula:

  C16H11Cl2N3O2S

• Molecular Weight:

  380.25

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Periodic Reporting for period 1-AMPK-DIAB (A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novelinnovative drug for the treatment of type 2 diabetes) .

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  1261289-04-6