AT7519 (TFA)

CAT: 0804-HY-50940A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-50940A-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
AT7519 (AT7519M) TFA as a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.
CAS Number
[1431697-85-6]
Product Name Alternative
AT7519M (TFA)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AT7519-trifluoroacetate.html
Purity
96.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CNN=C1C(NC2CCNCC2)=O)C3=C(Cl)C=CC=C3Cl.O=C(O)C(F)(F)F
Molecular Formula
C18H18Cl2F3N5O4
Molecular Weight
496.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Santo L, et al. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition. Oncogene. 2010 Apr 22;29 (16) :2325-36.|[2]Squires MS, et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.|[3]Squires MS, et al. AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol Cancer Ther. 2010 Apr;9 (4) :920-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9

Related Products

CatalogName
HY-50940-01AT7519
HY-50940R-01AT7519 (Standard)
HY-50943-01AT7519 (Hydrochloride)
HY-50943R-01AT7519 (Hydrochloride) (Standard)
HY-P0194ANocII (TFA)
HY-146231A-01SS47 (TFA)
HY-19648B-01Ebiratide (TFA)
HY-P2275B-01Peptide5 (TFA)
HY-114118A-01Semaglutide (TFA)
HY-P5423A-01GALA (TFA)

Alternative Products

CatalogName
MF-0063413AT7519 TFA
MF-0016428-01AT7519
GW4564-10mgAT7519 hydrochloride
MBS5757085AT7519 trifluoroacetate
A10093-5AT7519 5mg
S7808-5mgAT7519 HCl
A10093-100AT7519 100mg

Popular Products