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Barasertib

CAT: 0804-HY-10127-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10127-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Barasertib (AZD1152), a pro-drug of Barasertib-hQPA, is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib (AZD1152) induces growth arrest and apoptosis in cancer cells[1].
CAS Number
722543-31-9
Product Name Alternative
AZD1152
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD1152.html
Concentration
10mM
Purity
99.50
Solubility
DMSO : ≥ 33 mg/mL
Smiles
O=C(NC1=CC=CC(F)=C1)CC2=CC(NC3=C4C=CC(OCCCN(CC)CCOP(O)(O)=O)=CC4=NC=N3)=NN2
Molecular Formula
C26H31FN7O6P
Molecular Weight
587.54
References & Citations
[1]Yang J, et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007 Sep|[2]Oke A, et al. AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo. Cancer Res. 2009 May 15;69 (10) :4150-8.|[3]Wilkinson RW, et al. AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res. 2007 Jun 15;13 (12) :3682-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Aurora B

Alternative Products

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442111-01Barasertib
MBS130062-01Barasertib (AZD1152)
MBS132111-01AZD1152 (Barasertib)
FB32080-01Barasertib-HQPA
C07558-1gBarasertib (AZD1152-HQPA)

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