Tersolisib

• Description:

  STX-478 (compound 80) is an oral CNS-penetrant allosteric mutant-selective PI3Kα inhibitor. STX-478 shows robust and durable tumor regression and can be used in cancer research[1].

• Product Name Alternative:

  STX-478

• UNSPSC:

  12352005

• Target:

  PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/stx-478.html

• Concentration:

  10mM

• Purity:

  99.63

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  NC1=NC=C (C=N1) NC (N[C@H] (C2=C (C3=CC (F) =CC (F) =C3O2) C) C (F) (F) F) =O

• Molecular Formula:

  C16H12F5N5O2

• Molecular Weight:

  401.29

• References & Citations:

  [1]JR David St Jean, et al. Urea derivatives which can be used to treat cancer. Patent WO2022265993A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  2883540-92-7