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EGA

CAT: 0804-HY-125168-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125168-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGA is an inhibitor that selectively targets the endosomal trafficking pathways. EGA targets the proteins involved in the endosomal trafficking pathways through which multiple toxins and viruses enter cells. EGA exerts its activity by inhibiting the trafficking from early endosomes to late endosomes, blocking the entry of multiple acid-dependent bacterial toxins and viruses into mammalian cells and delaying the lysosomal targeting and degradation of EGFR[1].
CAS Number
415687-81-9
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H410
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ega.html
Purity
99.76
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
BrC1=CC=C(/C=N/NC(NC2=C(C)C=CC=C2C)=O)C=C1
Molecular Formula
C16H16BrN3O
Molecular Weight
346.22
Precautions
H315, H319, H335, H410
References & Citations
[1]Gillespie EJ, et al. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A. 2013 Dec 10;110 (50) :E4904-12.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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