Nicotinamide N-oxide

• UNSPSC Description:

  Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

• Target Antigen:

  CXCR; Drug Metabolite; Endogenous Metabolite; Oxidative Phosphorylation

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Nicotinamide_N-oxide.html

• Purity:

  99.85

• Solubility:

  DMSO : 10 mg/mL (ultrasonic)|H2O : 20 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=C[N+]([O-])=CC=C1)N

• Molecular Weight:

  138.126

• References & Citations:

  [1]Real AM, et al. Nicotinamide N-oxidation by CYP2E1 in human liver microsomes. Drug Metab Dispos. 2013 Mar;41(3):550-3.|[2]Cutshall NS, et al. Nicotinamide N-oxides as CXCR2 antagonists. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1951-4.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1986-81-8