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Nicotinamide N-oxide

CAT: 0804-HY-101407-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101407-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.
CAS Number
1986-81-8
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
CXCR; Drug Metabolite; Endogenous Metabolite; Oxidative Phosphorylation
Type
Natural Products
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Nicotinamide_N-oxide.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 20 mg/mL (ultrasonic)
Smiles
O=C(C1=C[N+]([O-])=CC=C1)N
Molecular Formula
C6H6N2O2
Molecular Weight
138.13
Precautions
H315, H319, H335
References & Citations
[1]Real AM, et al. Nicotinamide N-oxidation by CYP2E1 in human liver microsomes. Drug Metab Dispos. 2013 Mar;41 (3) :550-3.|[2]Cutshall NS, et al. Nicotinamide N-oxides as CXCR2 antagonists. Bioorg Med Chem Lett. 2001 Jul 23;11 (14) :1951-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CXCR2

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