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2′-O-Methyluridine-d3

CAT: 0804-HY-W011824S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W011824S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2′-O-Methyluridine-d3 is deuterium labeled 2′-O-Methyluridine. 2’-O-Methyluridine is a modified nucleoside that can be found in T. thermophile tRNA. 2’-O-Methyluridine can be incorporated into siRNA targeting the gene encoding apolipoprotein B, which decreases ApoB protein levels in HepG2 and prevents IFN-α production in isolated human PBMCs. 2’-O-Methyluridine level in serum is decreased in patients with breast cancer[1][2][3].
UNSPSC
12352005
Target
Apolipoprotein; Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Inflammation/Immunology
Purity
99.19
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@H](O)[C@@H](OC([2H])([2H])[2H])[C@H](N2C(NC(C=C2)=O)=O)O1
Molecular Formula
C10H11D3N2O6
Molecular Weight
261.25
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Aučynaitė A, et al. Identification of a 2'-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic Libraries. Molecules. 2018;23 (11) :2904. Published 2018 Nov 7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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