FPR-A14

FPR-A14

• CAS Number: 329691-12-5
• UNSPSC Description: FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation[1][2].
• Target Antigen: Formyl Peptide Receptor (FPR)
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/fpr-a14.html
• Purity: 99.90
• Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(C1=CC=C(OCO2)C2=C1)N/N=C/C3=CC=C(OCC4=CC=CC=C4)C(OC)=C3
• Molecular Weight: 404.42
• References & Citations: [1]Igor A Schepetkin, et al. High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. Mol Pharmacol. 2007 Apr;71(4):1061-74.|[2]Peter J G Cussell, et al. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically. inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 2019 Jun 6;14(6):e0217815.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported