Decanedioic acid

• Description:

  Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[1][2][3].

• Product Name Alternative:

  Sebacic acid

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/Decanedioic_acid.html

• Purity:

  99.96

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : 1 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  O=C(O)CCCCCCCCC(O)=O

• Molecular Formula:

  C10H18O4

• Molecular Weight:

  202.25

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Bertuzzi A, et al. Sebacic acid binding to human plasma albumin. Biochem Pharmacol. 1993 Feb 9;45 (3) :697-702.|[2]Angelini G, et al. Dodecanedioic acid prevents and reverses metabolic-associated liver disease and obesity and ameliorates liver fibrosis in a rodent model of diet-induced obesity. FASEB J. 2024 Nov 30;38 (22) :e70202.|[3]Salinari S, et al. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetic subjects. American Journal of Physiology-Endocrinology and Metabolism, 2006, 291 (5) : E1051-E1058.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  111-20-6